Health Technology Archives

World AIDS Day 2023 – What innovations are being developed for AIDS and HIV?

1st December 2023

What innovations are being developed for AIDS and HIV?

With an estimated 39.0 million [33.1–45.7 million] people living with HIV at the end of 2022, and with 630 000 [480 000–880 000] people dying from HIV-related causes in 2022 alone[i] finding new ways of preventing, diagnosing, and treating the disease is crucial. To mark World AIDS Day 2023 we take a look at what innovations are being made in the diagnosis, management, and treatment of AIDS. To do this we initially ran a search for (Human-immunodeficiency-virus or HIV) or (Acquired-immunodeficiency-syndrome or AIDS) and limited it to the last 5 years. During this time, there have been over 11k patent publications relating to AIDS and HIV.

Figure 1 shows the patents are in a variety of classifications, and we can identify over a quarter of the publications related to classification codes A61P31/18 (for HIV), A61P35/00 (Antineoplastic agents), and A61P43/00 (Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00).

Who is Innovating for HIV and AIDS?

Figure 2Figure 2 shows Merke, the National Institute of Health Nih, and Viiv Healthcare dominate. We’ll highlight a few of their patents below.

Merke

Publication number US11648250B2

Title: TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS

Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula Iand their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

This patent discloses Tetrahydroquinazoline derivatives and their use as HIV-Targeted Activator of Cell Kill agents which accelerate the death of HIV GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells.

National Institute of Health

Publication number US10815295B2

Title: BROADLY NEUTRALIZING HIV-1 ANTIBODIES THAT BIND TO THE CD4-BINDING SITE OF THE ENVELOPE PROTEIN

Abstract: Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.

This patent discloses A method for inhibiting a human immunodeficiency virus (HIV)-1 infection in a subject by administering monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120.

Viiv Healthcare

Publication number US2023106880A1 – INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Abstract: A compound of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection.

This application by Viiv Healthcare discloses novel compound that may be used in the treatment of human immunodeficiency virus (HIV) infection

[i] https://www.who.int/news-room/fact-sheets/detail/hiv-aids

Are you developing new inventions around AIDS and HIV?

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World Diabetes Day 2023 – What innovations are being developed for diabetes?

14th November 2023

What innovations are being developed for diabetes?

With 1 in 10 people living with Diabetes globally (537 million), and this is expected to rise to 643 million by 2030 and 783 million by 2045[i], finding new ways of preventing, diagnosing, and treating the disease is crucial. To celebrate World Diabetes Day 2023 we take a look at what innovations are being developed in the Health Technology sector relating to diabetes. To do this we initially ran a simple search on diabetes and isolated the search to the last five years publications only.

During this time, there have been almost 300k patent publications relating to Diabetes. As Figure 1 shows the patents are in a variety of classifications. However, almost a quarter of the publications relate to classification codes A61B5/145[ii] (Measuring Characteristics of Blood in Vito) and A61B5/00[iii] (Measuring for Diagnostic Purposes) and we will look at the innovators in this space and highlight a few of their patents.

Who are the main players in Diabetes Monitoring?

Figure 2 shows Roche, Dexcom, and Medtronic dominate, and we will showcase some of their recent patents.

Roche Diagnostics – Patent number US2020250939A1 MEDICAL DEVICE ALERT, OPTIMIZATION, PERSONALIZATION, AND ESCALATION

Figure 3 – Patent number US2020250939A1

This patent alerts the user via a message sent to their watch, smartphone, smart speaker, etc that their glucose levels have changed. The alerts will get progressively louder/stronger until the user acknowledges the message.

Dexcom – Patent number US2023138673A1 – RANKING FEEDBACK FOR IMPROVING DIABETES MANAGEMENT

This patent is a method for providing feedback based on glucose measurements. Readings are taken and analysed against historical data with alerts sent to the wearer advising if readings are higher/lower than normal at periodic times. Ways to make improvements are suggested if particular actions are taken, ie exercise activity.

Medtronic – Patent US2022143314A1 – DIABETES THERAPY BASED ON DETERMINATION OF FOOD ITEM

This patent by Medtronic discloses a method for adapting diabetes therapy based on what a person eats. Using a mixture of wearable devices and cameras, information is generated allowing therapy to be tailored to the individual based on their diet.

[i] https://worlddiabetesday.org/about/facts-figures/

[ii] A61B5/145:

Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; {Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue}(measuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06)

[iii] A61B5/00:

Measuring for diagnostic purposes (radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00); Identification of persons

Are you developing new inventions around Diabetes?